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Prednisone prevents the release of substances in the body that cause inflammation. It is used in different conditions including ulcerative colitis.

How should it be used?

This medication is available in tablet and liquid forms.

  • Take the tablet form with a full glass of water.
  • Take with food if it upsets your stomach.
  • If you are taking the liquid form, measure the dose with a special measuring spoon or cup, not a regular household spoon.
  • If you take only one time a day, take in the morning.
  • DO NOT stop taking this medicine without telling the doctor.
  • Ask the doctor ahead of time about what you should do if you miss taking a dose.

Special Precautions/Instructions

Before you start taking this medicine tell your doctor about any of the following:

  • All of the medications (including over the counter), vitamins, herbal products, and supplements you are taking.
  • Have a problem (hypersensitivity) to prednisone or anything in this medicine:
    • -tablets: prednisone, lactose, pregelatinized starch (corn), microcrystalline cellulose, sodium starch glycolate and magnesium stearate, (the 1, 2.5, and 5 mg strengths also contain stearic acid)
    • -liquid: prednisone, alcohol, citric acid, disodium edetate, fructose, hydrochloric acid, maltol, peppermint oil, polysorbate 80, propylene glycol, saccharin sodium, sodium benzoate, vanilla flavor and water.
  • Have a fungal infection
  • Are diabetic
  • Have liver or kidney problems
  • Are pregnant, plan on becoming pregnant, or breastfeeding.

DO NOT get vaccines like measles, mumps, rubella, polio, rotavirus, smallpox, typhoid, yellow fever, chickenpox, H1N1, influenza and nasal flu vaccine while taking this medicine. The vaccine may not work as well and may not fully protect you from the disease. Avoid exposure to anyone who has chickenpox or measles. Call your doctorimmediately if you are exposed to chickenpox.

Side Effects

The most common side effects include: moon face, thinning hair, increased susceptibility to infection, psychotic episodes, depression, growth suppression in children, & pancreatitis.

Call your doctor if you experience sudden weight gain or swelling.

Contact your doctor immediately if you experience signs of an allergic reaction including:

  • Diarrhea
  • Feeling sick
  • Fever, shivering/chills, rash
  • Muscle and bone pain
  • Kidney problems (changes in the amount of urine or color of urine)
  • Tiredness, dizziness
  • Itching
  • Swelling
  • Trouble breathing

Additional side effects may be found on the drug’s website: /Prescribing+Information/PIs/Roxane/Prednisone+Reformulated/PredniSONEReform.pdf

Storage Conditions

Store at room temperature away from moisture and heat.


Call the national poison control center 1-800-222-1222 or 911 in the event of overdose. Symptoms of an overdose include vomiting, diarrhea, sore throat, fever, chills, and other signs of infection.