Ursodiol (Actigall) helps dissolve gallstones in patients who cannot have or who do not need gallbladder surgery, or to help prevent gallstones in patients who are on rapid weight-loss programs. This medicine is also useful for certain liver diseases in adults, children and infants.

How should it be used?

This medication is available in tablet form.

  • Tablets should be swallowed with water – not chewed.
  • Take with food.
  • Take your doses at regular times. Do not take more than is directed, and take all of the medicine even if you feel better.
  • If you miss a dose, take it as soon as you can unless it is almost time for your next dose. Do not take double doses to make up for the one you forgot to take.

Special Precautions/Instructions

Before you start taking this medicine, tell your doctor about all of the following:

  • Medications (including over the counter), vitamins, herbal products, and supplements that you take before beginning this medication.
  • Accumulation of fluids in the abdominal cavity (ascites)
  • Veins that enlarge and bleed (bleeding varices)
  • Brain disease due to liver failure (hepatic encephalopathy)
  • Liver damage
  • Liver problems
  • Biliary tract problems
  • pancreatitis
  • Avoid taking this medication with antacids, estrogens, clofibrate, and hormonal contraceptives.

Side Effects

The most common side effects include: constipation, gas, indigestion or nausea.

Contact your doctor immediately if you experience:

  • Allergic reaction like skin rash, itching or hives, swelling of the face, lips or tongue
  • Trouble breathing
  • Diarrhea
  • Feeling sick
  • Fever, shivering/chills, rash
  • Muscle and bone pain
  • Kidney problems (changes in the amount of urine or color of urine)
  • Tiredness, dizziness

Storage Conditions

Store at room temperature in tightly closed container. Keep out of reach of children. Protect from sunlight and moisture.


Call the national poison control center 1-800-222-1222 or 911 in the event of overdose. Symptoms of an overdose include vomiting, diarrhea, sore throat, fever, chills, and other signs of infection.

Pediatric Use

The safety and efficacy of this drug in pediatric patients have not been established.

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